Use of Postexposure Prophylaxis After Occupational Exposure to Zaire ebolavirus.

Management of accidental exposure to Ebola virus in the biosafety level 4 laboratory, Hamburg, Germany.

A needlestick injury occurred during an animal experiment in the biosafety level 4 laboratory in Hamburg, Germany, in March 2009. The syringe contained Zaire ebolavirus (ZEBOV) mixed with Freund's adjuvant. Neither an approved treatment nor a postexposure prophylaxis (PEP) exists for Ebola hemorrhagic fever. Following a risk-benefit assessment, it was recommended the exposed person take an expe...

Recombinant vesicular stomatitis virus vector mediates postexposure protection against Sudan Ebola hemorrhagic fever in nonhuman primates.

Recombinant vesicular stomatitis virus (VSV) vectors expressing homologous filoviral glycoproteins can completely protect rhesus monkeys against Marburg virus when administered after exposure and can partially protect macaques after challenge with Zaire ebolavirus. Here, we administered a VSV vector expressing the Sudan ebolavirus (SEBOV) glycoprotein to four rhesus macaques shortly after expos...

Adults Often Source of Pertussis

rate of perinatal HIV transmission and to be beneficial in treating early HIV infection. However, the implications of these results for postexposure prophylaxis are uncertain. The short-term toxicity of ZDV in HCWs primarily has been gastrointestinal discomfort and fatigue. In 1990, the Public Health Service (PHS) concluded that a recommendation could not be made for or against the use of ZDV p...

Use of HIV Postexposure Prophylaxis in healthcare workers after occupational exposure: a Thai university hospital setting.

BACKGROUND PostExposure Prophylaxis (PEP) is widely used after exposures to Human Immunodeficiency Virus (HIV) to reduce the risk of infection in the healthcare setting. Few data are available on the safety and tolerability of Anti Retro Viral drugs (ARV) among Health Care Workers (HCWs) who are prescribed prophylaxis. OBJECTIVE To collect information about the safety and compliance of taking...

Differences between new United States recommendations and existing European guidelines on the use of postexposure prophylaxis (PEP) following non-occupational exposure.